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NHS to detect rare diabetes

People with a rare form of diabetes may receive better treatment and

discover whether their children are affected under new plans from NHS

England, The Guardian reports.

Monogenic diabetes occurs in two types: neonatal - which can present

in babies within the first six months - and maturity-onset diabetes of the

young that usually develops before 25. Approximately 12,000 people in

England have monogenic diabetes. However, it can be hard to distinguish

from Type 1 and Type 2 diabetes. Plans by NHS England to improve

diagnoses of monogenic diabetes will ensure there is training and support

for a designated nursing and medical lead in each NHS trust. Up to 280 staff

are to be trained on how to spot the condition over the next year. Among

the tools available to clinicians is an online probability calculator.

"Monogenic diabetes is difficult to diagnose, and we will more easily be

able to identify those who need to be referred for genetic testing by training

teams on monogenic diabetes in each trust," said Prof Partha Kar, NHS

national speciality adviser for diabetes.

The programme could help people receive better, more personalised

treatment to help them manage their glucose levels. Genetic testing can

also be used to determine whether the affected gene has been passed on to

other members of a family. To read more, CLICK HERE.

FDA approves

Lyumjev

Eli Lilly has received FDA approval

and expanded labelling for its

Lyumjev rapid-acting insulin.

Lyumjev is a novel formulation of

insulin lispro for speeding up insulin

absorption into the bloodstream and

reducing HbA1C levels over time. Lilly

says the insulin could help control

blood glucose levels after meals

in adults with diabetes, similar to

how natural insulin works in those

without diabetes.

FDA approval in June 2020 came

on the back of results from the

Pronto-Pump-2 phase 3 trial that

demonstrated efficacy and safety

for Lyumjev when used in insulin

pumps in adults with type 1 diabetes.

The study met the primary endpoint

of non-inferior A1C reduction from

baseline to week 16 compared to

Lilly's Humalog insulin while also

demonstrating a superior reduction

in blood glucose spikes at one and

two hours after a test meal, again

compared to Humalog.

Lilly VP of medical affairs Dr

Leonard Glass said in a news release,

"Insulin pumps are an important

delivery option for people with

diabetes - many of whom struggle

with high post-meal blood sugar

levels. The expansion of the Lyumjev

label to include use in an insulin

pump provides a new and important

choice for people with diabetes."

T1 & Tech

event

Diabetes UK's annual Type 1 and

Tech conference takes place

online on 16 October. The event

is free and open to anyone

affected by diabetes. Many

different topics will be covered

during the event, including issues

highlighted by coronavirus. Find

out more and REGISTER HERE.

Revita's 10th clinic

Fractyl Health has activated the 10th

clinical site in its REVITA-T2Di trial

in the United States and Europe. The

trial is a prospective, randomised,

double-blind, sham-controlled

study to evaluate the efficacy of

Fractyl's Revita DMR (duodenal

mucosal resurfacing) procedure.

According to a news release, the

company set a primary endpoint of

the percentage of those who can

achieve HbA1c less than or equal to

7% without the need for insulin at 24

weeks, comparing Revita DMR to the

sham arm.

In April, Fractyl secured FDA

breakthrough device designation for

its Revita DMR procedure designed

to resurface the upper intestine

lining in metabolic disease for

people with insulin-treated Type

2 diabetes. The company aims to

minimise or eliminate the need

for people with Type 2 diabetes to

receive insulin treatment through

the procedure.

The REVITA-T2Di trial is enrolling

people with Type 2 diabetes who

are currently on insulin therapy at

sites in New Jersey, Louisiana, Texas,

Massachusetts and New York to

add to the initial US site at Indiana

University Health. Enrolment is also

ongoing in Belgium, Italy and the

Netherlands.

www.fractyl.com

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