JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion

LIVINGLIVING

functional cure would also need to involve

replenishment of the lost beta cells.

Beta cell transplants have had

experimental success, although, as with

all transplants, recipients would need to

take life-long immunosuppressant drugs

to prevent rejection - and these have a

range of side effects. Scientists are now

looking at ways to replace the lost beta

cells without the need for transplants.

A team of scientists led by Dr

Francesca Spagnoli at King's College

London is trying to reprogram skin cells

so that they turn into bona fide pancreatic

beta cells. Skin cells have previously been

transformed into heart muscle, liver and

nerve cells using a similar technique and

so Dr Spagnoli is optimistic about the

results.

If successful, a person with type 1

could simply donate a small sample of

their own skin cells to a lab before having

them turned into functional beta cells

and reintroduced into the body to restore

insulin production. As the beta cells would

essentially be 'home-grown', there should

be no risk of rejection, removing the need

for immunosuppressant drugs.

Boosting beta cells

In the US, researchers are trying a different

approach. Professor Gregory Ku at the

University of California, San Francisco,

is leading a team who hope to kick-start

beta cell growth in people with type 1. In

the past, this has been problematic as

beta cells do not naturally divide and grow

very quickly.

However, his team has found a

molecular pathway that stimulates beta

cell growth and insulin production in mice.

The 'switch' which turns this pathway

on is also found in humans and so the

researchers are aiming to make a drug

to trigger beta cell growth in those with

depleted beta cells.

In Ontario, Canada, Professor Gerald

Prud'homme and his team at St. Michael's

Hospital are also aiming to boost beta cell

regeneration - but by using drugs which

are already on the shelves.

His team hope that two drugs

combined together - sitaglipin, which

is currently used in Type 2 diabetes

to increase insulin production, and

the nutritional supplement gammaAminobutyric acid (GABA) - will trigger

beta cell regeneration and increase

levels of a protein called Klotho, which is

important for beta cell health and survival.

An illustration of a

pancreatic gland.

The future's bright

Type 1 diabetes is a complex condition,

but with a two-pronged approach aiming

to replace lost beta cells and stop the

immune attack through immunotherapy,

at JDRF we believe that a cure is possible.

With the Type 1 charity's support,

scientists around the world are working

to make this happen.

www.jdrf.org.uk

Index

  1. Desang Diabetes Magazine, free diabetes magazine
  2. com CGM, continuous glucose monitoring
  3. Desang Diabetes Magazine, free diabetes magazine
  4. Desang Diabetes Magazine, free diabetes magazine, diabetes news
  5. Desang diabetes magazine, diabetes news, iLet insulin pump, Beta Bionics
  6. Desang diabetes magazine, diabetes news, Urgo Start footcare
  7. Diabetes UK Careline
  8. About a diabetic, Alexander Edenwind
  9. Medtronic Minimed 670G hybrid closed loop insulin pump
  10. Desang diabetes magazine, diabetes news, Teresa May
  11. Senseonics Eversense implantable CGM, Roche Diabetes Care, Accu-Chek
  12. Desang diabetes magazine, diabetes food news
  13. Desang Diabetes Diaries, Desang Diabetes Kitbags, Diabetes UK
  14. Desang diabetes magazine, diabetes food news
  15. HbA1c home test, A1C now, BHR Pharmaceuticals Ltd, home use A1C test, home use HbA1c test
  16. Desang diabetes magazine, diabetes food news,
  17. Desang diabetes magazine, diabetes food news,
  18. JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion
  19. JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion
  20. JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion
  21. Omnipod Insulet insulin pump with insulin pods, podders
  22. Desang Diabetes Magazine, free diabetes magazine
  23. Desang Diabetes Magazine, free diabetes magazine
  24. Desang diabetes magazine, diabetes stories, nothing beats a blood test, Agamatrix Wavesense Jazz
  25. Desang diabetes magazine, diabetes stories, nothing beats a blood test, GlucoRx HCT, Nipro Diagnosit
  26. Page 0026
  27. Desang diabetes magazine, nothing beats a blood test, Helen Spriggs IDEAL Group, Bayer Esprit Glucom
  28. Desang diabetes magazine, nothing beats a blood test, Helen Spriggs IDEAL Group, Bayer Esprit Glucom
  29. Abbott Freestyle Libre, Flash Glucose Monitoring, blood testing without lancets
  30. Desang diabetes magazine, nothing beats a blood test, Helen Spriggs IDEAL Group, Bayer Esprit Glucom
  31. censia Contour Next One Diabetes blood test meters
  32. Desang diabetes kitbags
  33. Diabetes travellers checklist
  34. Keeping diabetes technology stuck in place, Funky Pumpers, Rock Tape
  35. Decorating diabetes kit, CGM stickers
  36. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
  37. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
  38. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
  39. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
  40. Making Carbs Count, Giancarlo Caldesi
  41. Page 0041
  42. Making Carbs Count, Giancarlo Caldesi, The Diabetes Weight-loss Cookbook, Type 2 weight loss, low ca
  43. Accu-Chek Insight insulin pump for Animas users
  44. Desang diabetes magazine, free online diabetes magazine

Related Issues