JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion

LIVINGLIVING

ROGUE TYPE ONE

TOLERISATION

Two sides of the same coin, tolerisation is

the act of retraining the immune system

to end its attack on beta cells, while

restoring insulin production is known

as regeneration. Since 1970, JDRF has

supported scientists around the world in

researching all aspects of Type 1 diabetes

so that new therapies can be discovered

to cure, prevent and treat the condition.

In Type 1, the immune system

mistakenly mounts an inflammatory

attack on insulin-producing beta cells in

the pancreas. As a result, the beta cells

are destroyed and people with Type 1

can no longer make their own insulin.

Scientists hope that by retraining the key

immune cells in charge of the attack to

ignore - or tolerate - the beta cells, this

destruction could be stopped for good.

In conjunction with therapies to replace

the lost beta cells, this strategy has the

potential to cure Type 1.

In Cardiff, a team led by Professor

Susan Wong has successfully prevented

Type 1 development in mice by genetically

engineering a team of 'good' immune

cells to find 'rogue' T cells - key players in

the development of Type 1 - and kill them,

stopping their attack.

The team is now trying to use these

'good' immune cells to find and retrain

(rather than kill) rogue T cells to tolerate

beta cells. These newly 'tolerised' T cells

can then also find and retrain other rogue

T cells, potentially resulting in a much

more effective and long-lasting therapy.

Also in Cardiff, Professor Colin

Dayan and his team are trying a different

approach by developing patches of

microneedles, similar to velcro, that can

be placed painlessly onto the skin by

the user. The microneedles are coated

with small fragments of beta cells and

anti-inflammatory molecules and the

researchers hope that when the immune

system 'sees' the beta cell fragments

while being dampened down by the antiinflammatories, it

will learn to tolerate the

beta cells, preventing any further attack.

Parcel deliveries

A team led by Professor Giorgio Raimondi

at Johns Hopkins University, Maryland

USA, is aiming to retrain the immune

system in a similar way. Instead of

microneedles, they are using microscopic

parcels to deliver fragments of beta

cells, along with anti-inflammatories

and an immunotherapy, to immune

cells in the pancreas and the gut. As

with Professor Dayan's approach, they

hope that when the immune system

'sees' beta cell fragments whilst being

dampened down by anti-inflammatories

and immunotherapy, it will learn to tolerate

beta cells and stop the attack.

Also in the States, Professor Jay

Skyler at the University of Miami is trying

a different tactic by trialling a combination

of five existing immunotherapies to target

Type 1 from multiple angles. Although the

therapies have had some success in Type

The battle for the beta cell: An epic tale of tolerance and

regeneration. By Eleanor Sherwood, JDRF UK.

Index

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  7. Diabetes UK Careline
  8. About a diabetic, Alexander Edenwind
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  10. Desang diabetes magazine, diabetes news, Teresa May
  11. Senseonics Eversense implantable CGM, Roche Diabetes Care, Accu-Chek
  12. Desang diabetes magazine, diabetes food news
  13. Desang Diabetes Diaries, Desang Diabetes Kitbags, Diabetes UK
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  15. HbA1c home test, A1C now, BHR Pharmaceuticals Ltd, home use A1C test, home use HbA1c test
  16. Desang diabetes magazine, diabetes food news,
  17. Desang diabetes magazine, diabetes food news,
  18. JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion
  19. JDRF research Type One Diabetes beta cell tolerisation and beta cell regeneratwion
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  21. Omnipod Insulet insulin pump with insulin pods, podders
  22. Desang Diabetes Magazine, free diabetes magazine
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  26. Page 0026
  27. Desang diabetes magazine, nothing beats a blood test, Helen Spriggs IDEAL Group, Bayer Esprit Glucom
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  29. Abbott Freestyle Libre, Flash Glucose Monitoring, blood testing without lancets
  30. Desang diabetes magazine, nothing beats a blood test, Helen Spriggs IDEAL Group, Bayer Esprit Glucom
  31. censia Contour Next One Diabetes blood test meters
  32. Desang diabetes kitbags
  33. Diabetes travellers checklist
  34. Keeping diabetes technology stuck in place, Funky Pumpers, Rock Tape
  35. Decorating diabetes kit, CGM stickers
  36. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
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  39. Diabetic food ulcers, Urgo Start Plus, would healing, diabetic wound healing, diabetes footcare,
  40. Making Carbs Count, Giancarlo Caldesi
  41. Page 0041
  42. Making Carbs Count, Giancarlo Caldesi, The Diabetes Weight-loss Cookbook, Type 2 weight loss, low ca
  43. Accu-Chek Insight insulin pump for Animas users
  44. Desang diabetes magazine, free online diabetes magazine

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