A rendering of an immune system T cell.
"Immune retraining -
also called tolerisation
- seeks to stop Type 1
at the very core and, in
combination with beta
has huge potential to
be a realistic cure for
Replacing lost beta cells means restoring
insulin production. Type 1 diabetes is
an autoimmune condition whereby the
immune system mistakenly attacks and
destroys insulin-producing beta cells.
As a result, people with Type 1 can no
longer make their own insulin. JDRF funds
research into type 1 so that together we
can cure, prevent and treat the condition.
JDRF-funded scientists are working
on ways to train the immune system not
to attack beta cells - a process known
as tolerisation. However, upon diagnosis
withTtype 1, it's estimated that people have
just 10-30% of their beta cells left and so a
1 and other autoimmune conditions when
used separately, the team hopes that
combining them will simultaneously halt
the attack on beta cells while promoting
their health and survival - stopping Type
1 in its tracks.
Immune retraining - also called
tolerisation - seeks to stop Type 1 at the
very core and, in combination with beta
cell replenishment, has huge potential to
be a realistic cure for the condition.
The projects described here are just a
snapshot of the work that JDRF supports
in this research area and we are excited
and proud to be a part of the global fight
to cure, treat and prevent Type 1.