OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol

24

LIVING

Islet insights

An introduction to Oxford Centre for Diabetes,

Endocrinology and Metabolism (OCDEM) and the

Oxford DRWF Human Islet Isolation Facility,

by Sue Marshall.

Some people experience

very difficult diabetes

control, and in the case of

people who have extreme

hypoglycaemic unawareness, it can

lead to life-limiting circumstances

and severely reduced quality of

life. These people have little or no

symptoms that their blood sugars

are dropping, and can suddenly

find themselves in quite a severe

hypoglycaemic state as a result. This

is a dangerous way to live, as they

can be alone when this happens, or

out and about near traffic and so

forth, which is why solutions have

been sought to try and help people

who have severe hypo unawareness.

Pancreatic islet transplantation

has been the subject of research over

many decades but is now available on

the NHS in the UK in several centres,

for people who still have extreme

hypo unawareness despite optimal

conventional insulin treatment,

including the use of insulin pumps

and continuous glucose monitoring

(CGM). In the UK, there is currently

a waiting list of about 50 people who

have been deemed in need of such

surgery.

DRWF was set up as a charity to

fundraise in order to promote and

develop research to help all people

with diabetes. One of the projects it

has funded in the UK is the Human

Islet Isolation Facility based at the

Churchill Hospital in Oxford, part

of OCDEM (Oxford Diabetes Centre

for Endocrinology and Metabolism).

This is one of two centres in England

that can isolate clinical grade islets

from donor organs. The other is at

Kings College Hospital in London.

These two sites alternate, so that

one week islet cell isolation takes

place in Oxford, then the next week it

takes place at Kings. There is a small

network of six centres across the UK

where islet transplantation can take

place after the islet cells have been

isolated and transported. These are

Oxford, Kings (London), Newcastle,

Edinburgh, Manchester, and Royal

Free (London).

I was invited to visit the Human

Islet Isolation Facility and the Islet

Research Team in Oxford by DRWF,

and it was an extremely interesting

and heartening experience for me.

I am lucky enough that although I

have Type 1 diabetes, I do not qualify

for this procedure as I have a healthy

awareness of approaching low blood

sugars. While I would love to be

'cured,' the fact is that while this

procedure truly restores quality-oflife

to those who need it, there are

factors involved which means it is

not currently more widely available

or indicated. This includes, as with

any transplant, the relative risks of

having to take life-long anti-rejection

drugs (immunosuppression) after the

procedure. What I found on my visit

was an enthusiastic, knowledgeable

and dedicated team of people who

were entirely focused on getting

the very best outcomes for islet

isolation and transplantation to

Index

  1. Desang diabetes magazine, Making Carbs Count, Diabetes KIT, non-invasive glucose testing, OCDEM, Sig
  2. Desang diabetes, magazine diabetes information, Sue Marshall diabetes
  3. Desang diabetes, magazine diabetes information, Sue Marshall diabetes
  4. Desang diabetes magazine, diabetes news, beta cells, Abbott FreeStyle LIbre 3, FSL3
  5. insulin pump, Dana i system, artificial pancreas, Advanced Therapeutics UK, CamAPS FX, Dexcom G6
  6. diabetes news, diabetes research news, diabetes information, diabetes kit, diabetes technology, JDRF
  7. Dexcom G6 CGM, continuous glucose monitoring
  8. Dexcom G6 CGM, continuous glucose monitoring
  9. Medtronic Guardian Connect CGM sensor for diabetes
  10. diabetes news, diabetes research news, diabetes information, diabetes kit, diabetes technology
  11. Diabetes UK
  12. ViaCyte being bought by Vertex to advance cure for type 1 diabetes.
  13. Medtronic MiniMed 780G System Automated for an easier way to stabilise glucose levels
  14. ViaCyte being bought by Vertex to advance cure for type 1 diabetes.
  15. JDRF UK, DigiBete solutions for children and young adults with Type 1 diabetes.
  16. Hallmark Care Homes, DUET Diabetes, National Advisory Panel on Care Home Guidance, Professor Alan Si
  17. Hallmark Care Homes, DUET Diabetes, National Advisory Panel on Care Home Guidance, Professor Alan Si
  18. Problems facing people with diabetes in high weather temperatures from Diabetes UK.
  19. Ascensia GloucoContro diabetes blood test result sharing software
  20. Sigi Insulin Management System, AMP Medical, Sigi insulin pump.
  21. Desang diabetes, Inside Diabetes guides
  22. donation to UK diabetes charities JDRF and Diabetes UK.
  23. donation to UK diabetes charities JDRF and Diabetes UK.
  24. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
  25. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
  26. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
  27. Insulet Omnipod DASH insulin pump with insulin pods, podders, Omnipod DASH Personal Diabetes Manager
  28. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
  29. DRWF wellness days and events
  30. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  31. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  32. diabetes food news, diabetic diet, counting carbohydrates
  33. Diabetes technology education from Diabetes Technology Network DTN
  34. diabetes food news, diabetic diet, counting carbohydrates
  35. Medtrum Touchcare Nano Patch Pump and CGM
  36. Page 0036
  37. Abbott Freestyle Libre 2, Flash Glucose Monitoring, FSL2
  38. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
  39. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
  40. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes, anchovies and diab
  41. Desang diabetes kitbags, bag for diabetes kit
  42. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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