ViaCyte being bought by Vertex to advance cure for type 1 diabetes.

12

NEWS

Vertex to acquire ViaCyte

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Vertex to acquire ViaCyte, with the

goal of accelerating its potentially

curative VX-880 programmes in

Type 1 diabetes. ViaCyte brings

tools, technologies and assets

with potential to accelerate

development of VX-880, Vertex's fully

differentiated, insulin-producing,

stem cell-derived islets.

On July 11 2022 Vertex

Pharmaceuticals Incorporated

announced that the company

has entered into a definitive

agreement under which Vertex will

acquire ViaCyte, a privately held

biotechnology company focused on

delivering novel stem cell-derived cell

replacement therapies as a functional

cure for Type 1 diabetes (T1D), for

$320m.

Reshma Kewalramani, M.D.,

Chief Executive Officer and

President of Vertex, said, "VX-880

has successfully demonstrated

clinical proof of concept in T1D,

and the acquisition of ViaCyte will

accelerate our goal of transforming,

if not curing T1D by expanding our

capabilities and bringing additional

tools, technologies and assets to our

current stem cell-based programs."

Vertex's VX-880, an investigational

allogeneic stem cell-derived, fully

differentiated, insulin-producing

islet cell therapy for T1D, has

already achieved proof-of-concept

with highly promising safety and

efficacy results from an ongoing

Phase 1/2 study which continues

to enroll and dose patients. The

acquisition of ViaCyte provides

Vertex with complementary assets,

capabilities and technologies

including additional human stem cell

lines, intellectual property around

stem cell differentiation, and Good

Manufacturing Practice (GMP)

manufacturing facilities for cellbased

therapies that could accelerate

Vertex's ongoing T1D programmes.

The acquisition also provides access

to novel hypoimmune stem cell assets

via the ViaCyte collaboration with

CRISPR Therapeutics.

Michael Yang, President and Chief

Executive Officer of ViaCyte, added,

"ViaCyte's commitment to finding

a functional cure for T1D is shared

by Vertex, and this acquisition will

allow Vertex to deploy ViaCyte's tools,

technologies and assets toward the

development of Vertex's multiple cell

replacement therapy approaches

designed to reduce the burden

of millions of people living with

T1D worldwide."

By leveraging the studies of

developmental biology, ViaCyte

invented a reproducible, patented,

multistep process for differentiating

pluripotent stem cells into pancreatic

endoderm cells (also known as

pancreatic precursor cells; PEC-01

cells). The process mimics the natural

development of the human pancreas.

Index

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  12. ViaCyte being bought by Vertex to advance cure for type 1 diabetes.
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  24. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
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  28. OCDEM (Oxford Centre for Diabetes, Endocrinology and Metabolism and the Oxford DRWF Human Islet Isol
  29. DRWF wellness days and events
  30. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
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  33. Diabetes technology education from Diabetes Technology Network DTN
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  38. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
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  40. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes, anchovies and diab
  41. Desang diabetes kitbags, bag for diabetes kit
  42. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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