Omnipod 5 (Omnipod Horizon) advanced hybrid closed loop insulin pump

LIVINGLIVING

KIT THAT'S COMING SOON

A

n article written for JDRF

by Todd Boudreaux

summarised sessions

presented at this year's

annual (virtual) American

Diabetes Association (ADA) conference

about the new models of closed loop

insulin pump systems. Boudreaux writes,

"All studies referenced the Medtronic

780G system as Advanced Hybrid Closed

Loop (AHCL) - We have used 780G for

clarity. The first study highlighted results

from the pivotal trial of Medtronic's

next-generation 780G system. A few

key results from this study showed that

mean HbA1c improved across the group

from 7.5% at baseline to 7%. Also the

percentage of participants who achieved

70% (or greater) Time in Range (TIR)

improved from 54% at baseline to 73%

overall. Among adolescents the number

of participants hitting 70% Time in Range

(TIR) rose from 18% at baseline to 59%

overall. Overall TIR went from 68.8% to

74.5% on 780G. That number went from

71.2% up to 81.5% during overnight

hours (12am-6am.)

"Dr. Richard M Berganstal presented

results from the Fuzzy Logic Automated

Insulin Regulation (FLAIR) Study which

directly compared the 670G to the 780G

(AHCL) system. This 90-day trial across

seven international sites enrolled 113

adolescents and young adults (ages 14-

29) and showed that 780G adds automatic

correction boluses, which the 670G

system does not, and the 780G do not exit

auto mode in cases of hyperglycaemia.

The results showed that 780G improved

outcomes over 670G in all measures.

Both systems were found to be safe when

evaluating events of severe hypoglycaemia

or diabetic ketoacidosis (DKA). Another

significant point was that the time spent

in auto mode was significantly higher on

780G, 86% of the time, compared to 75%

for 670G. This amounted to an average of

5.7 exits of auto mode per week on 670G

and only 1.7 exits per week on 780G by

comparison.

On the horizon

Dr. Bruce Buckingham from Stanford

University presented the pre-pivotal trial

results from Insulet's Omnipod 5, powered

by Horizon. The Omnipod 5 (previously

Omnipod Horizon) algorithm lives on the

pod itself and communicates directly to

a Dexcom G6. It will be controlled via an

app on a Samsung smartphone device or

via a locked down touchscreen Personal

Diabetes Manager (PDM). The Omnipod

does not need to stay in range of a device

like current DIY Loop systems to operate

in hybrid closed loop mode.

The pre-pivotal study had 36

participants, 18 children (ages 6-13) and

18 adults (ages 14-70). Objectives were

to assess the safety and effectiveness

of the system at higher glucose targets

as well as giving the patients a wider

choice of target ranges. Omnipod 5

improved outcomes across the board,

with the biggest improvements coming

when patients were given the choice to

customize their own glucose targets.

During this 'free choice' testing over

4-9 weeks, TIR increased from 65.6%

in adults to 73.8%. Among children,

TIR increased from 51% to 70.1%. This

amounted to 17/18 children achieving

>60% TIR compared to just 4/18 on

standard therapy.

The next generation Omnipod 5

device is expected to be available in the

United States in the first half of 2021.

www.beyondtype1.org

Advanced Hybrid Closed Loop (AHCL) systems from Medtronic

and Insulet currently being studied in trials. An Omnipod from Insulet.

Index

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  10. Abbott Freestyle Libre, Flash Glucose Monitoring, iCGM
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  33. Medtronic Minimed 670G hybrid closed loop insulin pump
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  38. Free diabetes magazine, food news, lockdown
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  41. Insulet Omnipod DASH insulin pump with insulin pods, podders, Omnipod DASH Personal Diabetes Manager
  42. Free diabetes magazine, food news, lockdown
  43. Medtrum A6 Touchcare patch pump and CGM in harmony
  44. Free diabetes magazine, desang diabetes online magazine
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  48. Making Carbs Count, Carbohydrate counting for diabetes, fibre
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  51. Desang diabetes kitbags, bag for diabetes kit
  52. Desang diabetes magazine, free online diabetes magazine

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