JDRF stem cell encapsulation

LIVINGLIVING

An update on the encapsulation of precious insulin cells

funded by JDRF to treat Type 1 diabetes. By Rebecca Leitch,

who works at JDRF UK.

Encapsulation explained

As part of our research to find the cure

for Type 1 diabetes, JDRF is working to

develop techniques that will one day allow

people to regain insulin-producing beta

cells. In Type 1 diabetes, the beta cells

are killed off by the immune system, so

a technique called encapsulation is being

used to transplant new beta cells while

protecting them from another immune

attack. It is hoped that safely replacing the

lost beta cells for people living with T1D

will allow for the detection of changes in

blood glucose levels and the production

of insulin on demand - known as a

functional cure.

One encapsulation technique involves

protecting the transplanted beta cells

with a coating (alginate) that the immune

system doesn't respond to. Last August,

researchers in the US, partly funded by

JDRF, found an alginate in seaweed which

was able to coat and protect insulinproducing

beta cells for four months after

transplantation into monkeys, without the

need for immunosuppressant drugs. In

2016, JDRF supported the development

of a technique which involved weaving a

web of different molecules around sets of

islets (groups of beta cells) to create an

ultra-fine coating to protect them from

immune cells.

Another technique JDRF is supporting

is the development of a device that can

be implanted into the abdomen. This

product, developed by US company

ViaCyte, holds the cells safely inside the

device, which acts as a protective bubble

to keep them safe from immune attack.

Called the Encaptra system, it has holes

which are small enough to allow nutrients

through to enable the cells to live and

work, but won't let immune cells in.

Following the clinical trial at the

University of California, researchers found

that implanted cells survived and matured

into cells capable of producing hormones

including insulin and glucagon, but the

process of putting it inside the body

(engraftment) needs to be refined and

improved upon.

New options

There also is a newer encapsulation

product that is showing promising results

in this area. A firm has developed livecell encapsulation technology using

cellulose, a naturally-occurring plant

source that is free from impurities which

has been shown to last two years in the

body without breaking down or causing

damage to tissue nearby. The company

is working on encapsulating a human cell

line that has been designed to function as

a 'bio-artificial' pancreas when implanted

in a patient with Type 1 diabetes.

Finally, a team studying the protein

CXCL12 found it has a repellent effect on

immune cells and are using the protein to

drive immune cells away from the beta

cells they mistakenly try to attack in Type

1 diabetes.

Islet encapsulation has huge potential

to transform the lives of people with

Type 1 diabetes by eliminating daily

management of the condition. JDRF is

proud of the encapsulation projects that

we are supporting and is excited about

the potential of all the research happening

in this field, around the world.

www.jdrf.org.uk

ViaCyte's PEC-Encap (a also known as VC-01) is implanted

under the skin and delivers PEC-01 pancreatic progenitor

cells in the Encaptra immunoprotective device. These cells

are designed to further differentiate into mature pancreatic

cells that will synthesize and secrete insulin.

Index

  1. Desang diabetes magazine diabetes information
  2. Dexcom CGM, continuous glucose monitoring
  3. Desang diabetes magazine diabetes information, Sue Marshall
  4. Desang diabetes magazine diabetes news
  5. Desang diabetes magazine diabetes news
  6. Desang diabetes magazine diabetes news
  7. Page 0007
  8. Page 0008
  9. Medtronic Minimed 670G hybrid closed loop insulin pump
  10. Connected insulin pens, Novo Nordisk, Timesulin, Big Foot Biomedical, InsulCheck
  11. Connected insulin pens, Novo Nordisk, Timesulin, Big Foot Biomedical, InsulCheck
  12. Desang diabetes magazine diabetes diet
  13. Desang diabetes kitbags
  14. Page 0014
  15. HbA1c home test, A1C now, BHR Pharmaceuticals Ltd, home use A1C test, home use HbA1c test
  16. Page 0016
  17. Page 0017
  18. JDRF stem cell encapsulation
  19. Omnipod Insulet insulin pump with insulin pods, podders
  20. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  21. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  22. Blood test meters, nothing beats a blood test, CGM
  23. Blood test meters, nothing beats a blood test, CGM
  24. Ascensia Contour Next One Diabetes blood test meters
  25. ia Contour Next One Diabetes blood test meters
  26. Blood test meters, blood glucose meters, Kinetik Wellbeing, Ypsomed mylife Unio
  27. Ypsomed MyLife Diabetes care blood glucose monitoring systems
  28. Diabetes medications, Type 1 diabetes, Type 2 diabetes
  29. Diabetes Research and Wellness Foundation, DRWF Wellness Days
  30. Diabetes medications, Type 1 diabetes, Type 2 diabetes
  31. Ascensia Contour Next One Diabetes blood test meters
  32. Kit that's coming soon MyGrams smartphone scales
  33. Kit that's coming soon MyGrams smartphone scales
  34. Making Carbs count: Counting carbs for the diabetic diet
  35. Making Carbs Count teff
  36. Making Carbs Count teff
  37. Accu-Chek Insight insulin pump for Animas users
  38. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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