insulin pump, Dana RS system, artificial pancreas, Advanced Therapeutics UK, CamAPS FX, Dexcom G6

KIT

KIT

REPORT

CAM ON APP!

A closed loop insulin delivery app? What could that possibly be?

Welcome to the CamAPS FX, which I am about to explain (I hope!).

By Sue Marshall.

CamAPS FX, the world's

first closed loop

insulin delivery app,

has been developed

and researched over

the past 15 years by Professor Roman

Hovorka and his team at Addenbrooke's

Hospital in association with Cambridge

University. The diabetes charity JDRF

which has been funding this research for

many years hosted a webinar in July 2020

where Professor Hovorka explained the

app and took questions.

The webinar was presented by

actress Nina Wadia, whose son was

diagnosed two and a half years ago with

Type 1 diabetes, after passing out on an

airplane on the way home from a holiday.

Wadia recalled, "We went to hospital

when we landed and where nurse had

rather thoughtlessly said, 'don't you know

your son has diabetes?' Thankfully, later, a

consultant sat her down and calmly said,

'it is manageable.'

"At that point," Wadia remembers,

"I met the mother of another child with

diabetes at school, who told me that I

needed to be aware of JDRF and its work

to focus on prevention, treatment and

cure. Now he's a healthy 13-year-old and

I am extremely interested and happy to

support JDRF and its great work."

Also attending the webinar, Karen

Addington, CEO of JDRF UK, commented

on the new app describing it as, "The

world's first artificial pancreas closed loop

app." Also on the webinar was Rachel

Connor, the director of research and

partnerships for JDRF, who explained

that the app, "Mimics the healthy human

pancreas."

Professor Hovorka, the app's lead

inventor, explained, "The app sits on

any standard Android smartphone, so

long as the phone model can work with

the Dexcom app which pulls glucose

data in that the CamAPS app uses. It

also controls the insulin delivery. It's

also possible to bolus from the app

itself, direct from the phone. This means

that your insulin management can be

very discreet - extremely handy! But

what is key is that it learns and adapts

constantly. This is important, as we are

all different and everyday living with type

1 diabetes can be different. We believe

that this personalisation is another factor

that makes the app stand out. A user

can 'ease off' to relax insulin delivery for

exercise, and 'boost' to manage slightly

higher glucose levels when stressed. The

research and people using the app tell us

that it helps them get the best glucose

results for the least effort and makes

the burden of living with Type 1 diabetes

easier to manage.

He continued, "Inherently, as the

system relies on Continuous Glucose

Monitoring (CGM), users get all the other

benefits of CGM, which in the case of

Dexcom's CGM means no finger pricks.

Meanwhile, it automatically sends data to

the cloud so it is easy to monitor what is

happening - which is very reassuring for

parents and carers and makes keeping in

touch with the diabetes team simple too."

Less intrusive

As we are all aware, knowing about a

piece of diabetes tech is one thing. Getting

access to it is another. So who might

want to use this app, is it aimed at any

group in particular? Hovorka says, "At the

moment, it's been approved for anyone

over the age of one year old. They need a

smartphone, Dexcom CGM sensors and

a Dana RS or Dana-i insulin pump. In the

future we expect the app to work with

other CGM and pump devices. From the

point of installing and setting up the app,

it begins to modulate insulin delivery, all

the time. It's a much less intrusive system

than the other 'closed loop' or 'artificial

pancreas' systems. Not just in our view,

but it's been the view of people in the

clinical trials who have had experience of

using other systems. You can expect a

good night's sleep without interruptions.

You can expect improved control. People

on the clinical trials have said using the

app has been a life changing experience.

One person said they'd had the best

night's sleep in 15 years after using it. We

have seen an average of 10-15% more

time spent in range with less time spent in

hypo, as well as lowering HbA1c values."

All this has been proven in clinical trials

and via research. JDRF supported these

with research grants, as well as being the

reason for this research as, says Hovorka,

"We share the desire to ease the burden

of people living with Type 1 diabetes."

Currently, the app is available for

anyone who wants to self-fund. So, what

about reimbursement on the NHS? "In

Index

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  13. Abbott Freestyle Libre, Flash Glucose Monitoring
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