Stem cells and gene editing for a cure to Type 1 diabetes.

23

LIVING

The clinics offering it are bullish though. Press

coverage for TruStem Cell Therapy in Lake Forest

in the US, which uses stem cells from patient's own

bone marrow, states 'Receiving stem cell therapy

for diabetes Type 2 has the potential to improve

a patient's quality of life significantly by reducing

symptoms and complications as well as slowing its

progression. For patients receiving stem cell diabetes

treatment, it is possible to see improvements in any

one or multiple disease-related complications such

as stabilisation of blood sugar levels, lower blood

sugar levels, frequent urination, fatigue [and] poor

wound healing.'

It also seems possible that research on gene

function will identify a way to switch off the immune

system malfunction which causes the attack on the

body's own beta cells in the first place.

Another company hot on the heels of Vertex in

the contest to produce a workable diabetes cure, is

ViaCyte, in San Diego, California, which is aiming to

combine gene editing with stem cell transplantation.

In February, the company announced that a treatment

code named VCTX210 developed in collaboration

with gene-editing company CRISPR Therapeutics, is

about to be used for the first time in someone with

T1D. It is described as 'an investigational gene-edited

product derived from the patient's own stem cells

for the creation of pancreatic cells designed to evade

recognition by the immune system and enable patients

to produce their own insulin.'

The project's key clinical investigator is James

Shapiro, director of the Islet Transplant Program at

the University of Alberta, Canada, who is another of

the world-class experts in the field. He says, "We are

excited to work with CRISPR Therapeutics and ViaCyte

to carry out this historic, first-in-human transplant

of gene-edited, stem cell-derived pancreatic cells

for the treatment of diabetes, designed to eliminate

the need for immune-suppression. If this approach is

successful, it will be a transformative treatment for

patients with all insulin-requiring forms of diabetes."

On demand?

Who knows if the breakthrough will come from

Alberta, Canada, Boston, Massachussetts, Kingston,

Surrey or somewhere else? We can be sure

though with such investment and such demand, a

breakthrough may not be far away.

GLOSSARY

CRISPR

From yourgenome.org: Full name CRISPR-Cas9

is a Nobel Prize-winning technology that enables

scientists to rewrite the genetic code in almost any

organism while being more cost-effective and precise

than any of its gene-editing predecessors. But this

technology also comes with ethical, security, and

monetary challenges. Read more HERE.

From LiveScience.com: In popular usage, CRISPR

(pronounced 'crisper') is shorthand for CRISPRCas9.

CRISPRs are specialized stretches of DNA, and

the protein Cas9 - where Cas stands for 'CRISPRassociated'

- is an enzyme that acts like a pair of

molecular scissors, capable of cutting strands of DNA.

CRISPR technology was adapted from the

natural defence mechanisms of bacteria and

archaea, a domain of relatively simple single-celled

microorganisms. These organisms use CRISPR-derived

RNA, a molecular cousin to DNA, and various Cas

proteins to foil attacks by viruses. To foil attacks, the

organisms chop up the DNA of viruses and then stow

bits of that DNA in their own genome, to be used as

a weapon against the foreign invaders should those

viruses attack again.

The acronym 'CRISPR' stands for Clusters of

Regularly Interspaced Short Palindromic Repeats' and

describes a region of DNA made up of short, repeated

sequences with so-called 'spacers' sandwiched

between each repeat.

Gene editing

Genome editing (also called gene editing) is a group

of technologies that give scientists the ability to

change an organism's DNA. These technologies allow

genetic material to be added, removed, or altered at

particular locations in the genome. Several approaches

to genome editing have been developed, the most

successful is CRISPR

Stem cells

These are retrieved from a tiny human embryo a few

days after fertilisation, when it consists of only 50-

150 cells. These early cells contain the genetic code

to be turned into any tissue in the human body, and

scientists are now working on ways to reprogramme

them in a laboratory and use them as repair patches

to replace defective adult cells. The success from

Brian Shelton's treatment with transplanted lab-grown

pancreatic beta cells is very promising.

Lois Rogers is an award-winning international journalist

and communications advisor specialising in healthcare

and life sciences.

Index

  1. Free online Desang diabetes magazine, diabetes information
  2. Free online Desang diabetes magazine, diabetes information
  3. Free online Desang diabetes magazine, diabetes information
  4. Desang diabetes magazine, diabetes news
  5. insulin pump, Dana i system, artificial pancreas, Advanced Therapeutics UK, CamAPS FX, Dexcom G6
  6. Desang diabetes magazine, diabetes news
  7. Abbott Freestyle Libre 2, Flash Glucose Monitoring, FSL2
  8. Desang diabetes magazine, diabetes news
  9. Glooko diabetes data download software. Stay on track in between visits.
  10. Page 0010
  11. Air Liquide Healthcare UK, Tandem t:slim insulin pump with Control IQ
  12. Desang diabetes magazine article on new NICE guidelines April 2022 spur far wider access to diabetes
  13. Home test HbA1c, A1C Now Self-Check
  14. Desang diabetes magazine article on new NICE guidelines April 2022 spur far wider access to diabetes
  15. Medtrum Touchcare Nano Patch Pump and CGM
  16. Diabetes technology, CGM sensors, FreeStyle Libre, Dexcom One, Glucorx Aidex CGM
  17. Diabetes technology, CGM sensors, FreeStyle Libre, Dexcom One, Glucorx Aidex CGM
  18. New drugs to replace insulin, replacing or preserving beta cells in people with type 1 diabetes.
  19. New drugs to replace insulin, replacing or preserving beta cells in people with type 1 diabetes.
  20. Stem cells and gene editing for a cure to Type 1 diabetes.
  21. Medtronic MiniMed 780G System Automated for an easier way to stabilise glucose levels
  22. Page 0022
  23. Stem cells and gene editing for a cure to Type 1 diabetes.
  24. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  25. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  26. JDRF's pathway to choice project for accdss to diabetes technology.
  27. JDRF's pathway to choice project for accdss to diabetes technology.
  28. Desang diabetes magazine, diabetes diet
  29. Diabetes technology education from Diabetes Technology Network DTN
  30. Desang diabetes magazine, diabetes diet
  31. Insulet Omnipod DASH insulin pump with insulin pods, podders, Omnipod DASH Personal Diabetes Manager
  32. Desang diabetes magazine, diabetes diet
  33. Desang diabetes magazine, diabetes diet
  34. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
  35. Making Carbs Count, Carbohydrate counting for diabetes, Desang diabetes magazine
  36. Making Carbs Count, Carbohydrate counting for diabetes, Desang diabetes magazine
  37. Desang diabetes kitbags, bag for diabetes kit
  38. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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