Stem cells and gene editing for a cure to Type 1 diabetes.

20

LIVING

Gene genie

Stem cells and gene editing - when will people with

diabetes reap the benefits? By Lois Rogers.

Stem cell technology is just around the corner as

a treatment for diabetes, putting the prospect of

a cure for Type 1 tantalisingly close and offering

the prospect of a life-transforming treatment for

millions more people with the Type 2 condition.

In Type 1 diabetes a malfunction in the body's

defensive immune system causes it to attack and destroy

the insulin-producing beta cells in the pancreas. Now

stem cell technology is set to block or even reverse that

malfunction.

For years, scientists have experimented with using

transplanted pancreatic beta cells from human donors

but recipients needed the same toxic anti-rejection drugs

given to people who receive whole organ transplants.

The problem was even more of a challenge because

donor cells, retrieved at the same time as organ donation,

are hard to come by, they don't produce the quantities of

insulin needed by people with T1D and recipients of the

donated beta cells often far worse illness from the antirejection

drugs than the illness caused by the diabetes

itself. However, it now seems possible for those cells to

be grown in a laboratory from stem cell lines originally

derived from donated human embryos.

Embryonic stem cells are collected a few days after

fertilisation when the cell ball consists of only 50-150

individual cells. These early cells contain the genetic code

to be turned into any tissue in the human body. Although

recipients still have to take anti-rejection drugs, these

embryonic stem cells hold out the promise of working

much better than adult cells. Scientists are now working

on ways to reprogramme them in a laboratory and use

them as repair patches to replace defective adult cells in

all sorts of functions - not just the pancreas, but also the

heart and other organs.

Latest step

The latest step came last year in America with news of

the first highly successful insulin-producing stem cell

transplant into Brian Shelton, a 64-year-old postman

from Elyria, Ohio, whose hypoglycaemia from Type 1

diabetes was so severe he would lose consciousness

without warning. He had repeatedly been found collapsed

and injured while delivering mail, and on one occasion

had crashed his motorbike into a wall.

He is the first patient from the Phase 1/2 clinical trial

of VX-880, an investigational stem cell-derived, fully

differentiated pancreatic islet cell replacement therapy

Index

  1. Free online Desang diabetes magazine, diabetes information
  2. Free online Desang diabetes magazine, diabetes information
  3. Free online Desang diabetes magazine, diabetes information
  4. Desang diabetes magazine, diabetes news
  5. insulin pump, Dana i system, artificial pancreas, Advanced Therapeutics UK, CamAPS FX, Dexcom G6
  6. Desang diabetes magazine, diabetes news
  7. Abbott Freestyle Libre 2, Flash Glucose Monitoring, FSL2
  8. Desang diabetes magazine, diabetes news
  9. Glooko diabetes data download software. Stay on track in between visits.
  10. Page 0010
  11. Air Liquide Healthcare UK, Tandem t:slim insulin pump with Control IQ
  12. Desang diabetes magazine article on new NICE guidelines April 2022 spur far wider access to diabetes
  13. Home test HbA1c, A1C Now Self-Check
  14. Desang diabetes magazine article on new NICE guidelines April 2022 spur far wider access to diabetes
  15. Medtrum Touchcare Nano Patch Pump and CGM
  16. Diabetes technology, CGM sensors, FreeStyle Libre, Dexcom One, Glucorx Aidex CGM
  17. Diabetes technology, CGM sensors, FreeStyle Libre, Dexcom One, Glucorx Aidex CGM
  18. New drugs to replace insulin, replacing or preserving beta cells in people with type 1 diabetes.
  19. New drugs to replace insulin, replacing or preserving beta cells in people with type 1 diabetes.
  20. Stem cells and gene editing for a cure to Type 1 diabetes.
  21. Medtronic MiniMed 780G System Automated for an easier way to stabilise glucose levels
  22. Page 0022
  23. Stem cells and gene editing for a cure to Type 1 diabetes.
  24. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  25. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  26. JDRF's pathway to choice project for accdss to diabetes technology.
  27. JDRF's pathway to choice project for accdss to diabetes technology.
  28. Desang diabetes magazine, diabetes diet
  29. Diabetes technology education from Diabetes Technology Network DTN
  30. Desang diabetes magazine, diabetes diet
  31. Insulet Omnipod DASH insulin pump with insulin pods, podders, Omnipod DASH Personal Diabetes Manager
  32. Desang diabetes magazine, diabetes diet
  33. Desang diabetes magazine, diabetes diet
  34. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
  35. Making Carbs Count, Carbohydrate counting for diabetes, Desang diabetes magazine
  36. Making Carbs Count, Carbohydrate counting for diabetes, Desang diabetes magazine
  37. Desang diabetes kitbags, bag for diabetes kit
  38. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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