Page 0008

NEWS

BETA-CELL REGENERATION?

A new study in mice has found that a

targeted combination of drugs can restore

beta cell function and achieve beta-cell

redifferentiation, which could eventually

open new ways for diabetes remission.

The study, by scientists at Helmholtz

Zentrum München in collaboration with

Novo Nordisk, defined seven cohorts

of severely diabetic mice and treated

them daily for 100 days with single and

a combination of drugs. The researchers

showed that a stable glucagonlike peptide-1 (GLP-1)/oestrogen

combination (provided by Novo Nordisk)

enables targeted and selective delivery

of the nuclear hormone cargo to beta

cells. This drug combination and a longacting insulin were

superior to singular

treatments to both normalise glycemia,

glucose tolerance, to increase pancreatic

insulin content and to increase the number

of beta cells.

Importantly, administration of high

doses of GLP-1/oestrogen did not show

signs of systemic toxicity in rats, a prerequisite

for any future clinical testing. In

collaboration with the biotech company

InSphero, the researchers could also

show that GLP-1/oestrogen, but not

GLP-1 or oestrogen alone, increases

human beta-cell function when human

pancreatic islets are exposed to cytokine

stress, which is known to impair human

beta-cell function.

The results from this study may pave

the way for clinical studies that use GLP-1

as a carrier peptide for oestrogen but

potentially also other, novel cargos to

directly target beta cells for regenerative

therapy and diabetes remission.

The results were published in Nature

Metabolism.

DIABETES

ON FILM

Diabetes UK is shortlisted in this year's

Charity Film Awards. The film, You're Not

Alone: The Emotional Impact of Diabetes

follows five people living with diabetes for

a week and highlights that you don't have

to be alone with the condition. Winners

are due to be announced in the spring.

Index

  1. Page 0001
  2. Dexcom CGM, continuous glucose monitoring
  3. Page 0003
  4. Page 0004
  5. Abbott Freestyle Libre, Flash Glucose Monitoring
  6. Page 0006
  7. Medtronic Guardian Connect
  8. Page 0008
  9. Page 0009
  10. Page 0010
  11. BD, Becton Dickinson, injection technique, BD pen needles
  12. Page 0012
  13. Home test HbA1c, A1C Now Self-Check
  14. Page 0014
  15. Medtronic Minimed 670G hybrid closed loop insulin pump
  16. Page 0016
  17. Association of British Clinical Diabetologists, Diabetes Technology Network, Libre Flash education p
  18. Page 0018
  19. Page 0019
  20. Page 0020
  21. Page 0021
  22. NHS UK coronovirus information
  23. Second Nature lifestyle behaviour change
  24. Carbs & Cals, Chris Cheyette, Yello Balolia, Making Carbs Count
  25. Carbs & Cals, Chris Cheyette, Yello Balolia, Making Carbs Count
  26. Carbs & Cals, Chris Cheyette, Yello Balolia, Making Carbs Count
  27. Diabetes UK helpline
  28. Page 0028
  29. Page 0029
  30. Nemaura Medical, Faz Chowdhury, sugarBEAT, BEATdiabetes, glucose sensor, glucose sensor for Type 2 d
  31. Nemaura Medical, Faz Chowdhury, sugarBEAT, BEATdiabetes, glucose sensor, glucose sensor for Type 2 d
  32. Nemaura Medical, Faz Chowdhury, sugarBEAT, BEATdiabetes, glucose sensor, glucose sensor for Type 2 d
  33. Nemaura Medical, Faz Chowdhury, sugarBEAT, BEATdiabetes, glucose sensor, glucose sensor for Type 2 d
  34. Page 0034
  35. Page 0035
  36. Page 0036
  37. Page 0037
  38. Page 0038
  39. Omnipod Insulet insulin pump with insulin pods, podders
  40. Page 0040

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