Hypo Metrics research study Kings College London

16

ENGAGE

Help define a hypo

By joining this study, you could contribute to a greater

understanding of how low blood sugars affect our

quality of life, an update by Susannah Hickling.

A

research study that aims

to improve understanding

of the effect of

hypoglycaemia on people

living with insulin-treated diabetes

is looking to recruit its last few

participants.

The Hypo-METRICS

(Hypoglycaemia: MEasurement,

ThResholds and ImpaCtS) project

is finalising the recruitment of 600

participants who have either Type

1 diabetes or Type 2 diabetes and

who use insulin at least once a day.

They should have had at least one

hypo in the previous three months.

In particular, the research team is

still hoping at this stage to recruit

just a few more participants with

Type 1 who have normal awareness

of hypoglycaemia, along with some

more people with Type 2 who are on

insulin. People using a closed loop

system are not eligible. The Chief

Investigator is Prof. Pratik Choudhary

of the University of Leicester and

King's College London.

The study involves answering a

short series of questions related to

how hypoglycaemia may affect you

via your smartphone several times a

day for 10 weeks. At the same time,

the researchers will use a Freestyle

Libre 2 continuous glucose monitor

(CGM) and a Fitbit Charge 4 activity

monitor that will collect information

about your sleep, activity and glucose

levels.

Devices will be supplied to

participants. You do not need to have

used them before. The CGM data will

be 'blinded', which means only the

research team sees the data, not you,

though you can have access to it at

the end of the trial. But as researcher

Dr Patrick Divilly, points out, "If

someone is already using CGM, they

can continue to use their current

form of monitoring, and this would

be an additional blinded sensor."

Participants will be able to keep

the Fitbit and will also receive a £100

voucher.

The results of this study will be

used to create a new definition of

hypoglycaemia using CGM, as well

as determine the impact of hypos on

people with diabetes, on their quality

of life as well as the health-economic

consequences of hypoglycaemia. This

is an observational study, so there

will be no changes to your diabetes

treatment.

Detecting lows

Says Divilly, "By using CGM devices

we have found that glucose levels

can be low without the person being

aware, but we don't know if these

undetected low glucose levels have

an impact on their health or daily

life. We will look at how long glucose

needs to be below a certain level

before people are likely to recognise

it and intervene to treat it. We will

also work out how periods of low

glucose affect people's sleep, mood,

and work, and whether being able

to recognise their hypos makes any

difference to this."

It is known that different

people can pick up symptoms of

hypoglycaemia at different glucose

levels, and sometimes even the same

person can experience symptoms of

hypoglycaemia at different levels. By

studying a large number of people

over 10 weeks, the study aims to

be able to define CGM-detected

hypoglycaemia that has a clinical

impact. "This is important to help

people with diabetes optimise

their diabetes self-management,"

says Divilly, "It will also allow us to

compare different treatments for

diabetes in terms of their risk for

causing hypoglycaemia that has

clinical, emotional or social impact."

While there will be no direct

medical benefit to anyone taking part

in the study, Divilly believes there

are two important reasons to take

part. "Firstly, based on the current

evidence, the definition of what a

hypo is on CGM is only accurate

20-40% of the time. That's not

reflecting the experience of people

living with diabetes, so this study is

an opportunity for people living with

diabetes to let us know and give us

the input of what kind of duration

and timeframe the sensor needs to

Dr Patrick Divilly.

Index

  1. Desang diabetes magazine, Making Carbs Count, Diabetes KIT, hypo Metrics
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  10. Steve Morgan Foundation historic £50m donation
  11. Air Liquide Healthcare UK, Tandem t:slim insulin pump with Control IQ
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  13. Home test HbA1c, A1C Now Self-Check
  14. Diabetes UK diabetes is serious campaign
  15. Ascensia GloucoContro diabetes blood test result sharing software
  16. Hypo Metrics research study Kings College London
  17. Hypo Metrics research study Kings College London
  18. Research candidates required Older Type 2s on insulin
  19. Desang Diabetes Magazine Qic Awards diabetes 2022
  20. Desang device report ATTD 2022 diabetes technology
  21. Desang device report ATTD 2022 diabetes technology
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  23. Abbott Freestyle Libre 2, Flash Glucose Monitoring, FSL2
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  25. Insulet Omnipod DASH insulin pump with insulin pods, podders, Omnipod DASH Personal Diabetes Manager
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  27. Innovation Zed InsulCheck insulin pen solutions
  28. Desang Diabetes magazine article on social prescribing
  29. Medtronic MiniMed 780G System Automated for an easier way to stabilise glucose levels
  30. Desang Diabetes magazine article on social prescribing
  31. Medtrum Touchcare Nano Patch Pump and CGM
  32. Free online Desang Diabetes magazine
  33. Free online Desang Diabetes magazine
  34. Desang diabetes magazine, diabetes diet
  35. Diabetes technology education from Diabetes Technology Network DTN
  36. desang diabetes magazine, diabetes diet, diabetic diet, counting carbohydrates, food for diabetes
  37. desang diabetes magazine, diabetes diet, diabetic diet, counting carbohydrates, food for diabetes
  38. Desang diabetes magazine, diabetes news
  39. Desang diabetes, Inside Diabetes guides, guide to injecting insulin, guide to injecting for people w
  40. Carbs count: Counting carbs for the diabetic diet
  41. Carbs count: Counting carbs for the diabetic diet
  42. Making Carbs Count
  43. Desang diabetes kitbags, bag for diabetes kit
  44. Desang diabetes magazine, free online diabetes magazine

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