Desang diabetes magazine, diabetes news

NEWS

5 MILLION EYE

TESTS MISSED

Our original giveaway in the August News Digest was for x10 Autolet devices from Owen

Mumford, but as we had a fair few applications, the company kindly extended this to

20 units all of which were then sent out. "I have received the lancing device today, very

impressed with the facility to adjust both the penetration depth and the force," said

reader Philip Bailey, based in Derbyshire. www.owenmumford.co.uk

Eye Health UK has revealed five million

routine eye tests were missed during

lockdown, while reduced capacity for

sight tests in opticians, due to Covid-19

safety measures, means further delays in

diagnosing and treating sight-threatening

eye conditions, such as glaucoma and

macular degeneration.

Prompt diagnosis and treatment is the

best defence in controlling eye disease

and preventing avoidable sight loss for

the estimated six million people in the UK

living with sight-threatening conditions or

uncorrected refractive error (for example

short-sightedness).

To ensure prompt diagnosis and

treatment, people are advised to contact

their optician immediately if:

• your vision has suddenly changed

or become blurry

• you have a painful or red eye

• you have been referred by NHS

111, your GP practice or another

healthcare professional

• you have broken or lost your

glasses and can't function

properly without them

• you have a problem with your

contact lenses

• you have a foreign body in your

eye

• you are worried about your vision

or eye health.

The figures were launched to mark

National Eye Health Week (21-27

September 2020). Minister for Prevention,

Public Health and Primary Care, Jo

Churchill said: "Eye care services are

open and practising safely across the

country to provide advice and support in

Covid-secure environments. I would urge

everyone to take care of their sight and

have it tested regularly."

Owen Mumford lancing device winners

An innovative new vaccine for Type 1

diabetes is being developed, which

reverses certain immune responses rather

than activating the immune system.

"We are trying to educate the immune

system to teach it what not to do," Bart

O. Roep, Chan Soon-Shiong Shapiro

Distinguished Chair in Diabetes at City

of Hope and professor/chair of the

Department of Diabetes Immunology

said. "It is a radical approach that does

not involve immunosuppression - it

engages the immune system and causes

desensitization, like allergy treatments."

The vaccine is reported to be safe

based on results from a small Phase I

trials. The process begins by taking blood

from the patient and isolating certain

white blood cells. These are then turned

into special immune cells called dendritic

cells - key regulators that help train other

immune cells to recognise invading

pathogens. The dendritic cells are then

grown for six days in liquid containing

vitamin D3. As well as being important

for calcium regulation and bone health,

vitamin D3 also regulates the immune

system, causing anti-inflammatory

effects.

The anti-inflammatory dendritic cells

will encourage other Type 1 diabetescausing immune cells to ignore

insulinproducing

beta cells, preventing their

destruction. Two days before the cellbased vaccine is given to the patient,

the dendritic cells are thawed and

treated with a fragment of proinsulin, a

precursor protein to insulin. Proinsulin is

an autoantigen that provokes the immune

system to destroy insulin-producing cells

in T1D patients.

These 'trained' dendritic cells regulate

the patient's immune system by training

T-cells not to attack proinsulin. Once in

the patient, the dendritic cells from the

vaccine induce regulatory T-cells (Tregs),

which regulate other immune cells, such

as the ones that attack insulin-producing

cells in the pancreas. The vaccine is

administered in two injections by a patch

near the pancreas one month apart, as a

primer and a boost.

www.biospace.com

'INVERSE' VACCINE FOR T1D

The FDA has approved Lilly's Lyumjev rapid-acting mealtime insulin to reduce

high blood sugar after meals and keep blood glucose levels in-range. This

approval offers another important mealtime insulin option for adults with Type

1 or Type 2 diabetes and was approved in Japan and Europe in March 2020.

Lyumjev can be taken at the beginning of a meal (recommended) or 20 minutes

after starting it. This flexibility is due to the faster onset and offset of the insulin.

US approval for Lyumjev

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  28. Insulet Omnipod DASH insulin pump with insulin pods, Omnipod CEO Shacey Petrovic
  29. Abbott Freestyle Libre, Flash Glucose Monitoring
  30. Insulet Omnipod DASH insulin pump with insulin pods, Omnipod CEO Shacey Petrovic
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  32. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
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