Desang diabetes magazine diabetes news, Diabetes UK Wales

NEWS

Awen-Haf and Llion Harding, aged

9 and 7, from Pontypridd decided to

double Diabetes UK's One Million Step

Challenge between July and September,

raising £315 for Diabetes UK Cymru.

The children's father, Scott, has Type

1 diabetes and this is the third time the

family has taken on the walking challenge.

Their mother, Marie Harding, said,

"As a family, we usually take on similar

challenges and take part in annual

fundraising activities for a cause close to

our hearts. The children have journeyed

with their dad, as he moved from injections

to pump to control his diabetes. This

was an ideal challenge during lockdown.

They wrote postcards to their friends and

walked to deliver them. They also enjoy

the outdoors in any weather and are used

to it, so the rain didn't bother them at all."

The challenge took them to beaches,

coastal paths, mountains, castles and

other Welsh landscapes. They ended up

doing an impressive 2m steps in 90 days.

Dai Williams, National Director of

Diabetes UK Cymru, said: "This year

we've seen demand for our services

reach record levels, while our own funding

KIDS 2M STEPS FOR CHARITY

has been significantly impacted. More so

than ever, people with diabetes in Wales

need us, but we need your support to

be able to continue fighting their corner.

Thank you to Awen-Haf and Llion for

their amazing effort and taking on the

One Million Step Challenge, you're both

incredible."

www.diabetes.org.uk/wales

PILL REDUCES

HBA1C IN T1D

An investigational once-daily pill added to

optimised insulin therapy has been shown

to reduce HbA1c among adults with T1D

during a 12-week trial when compared

with a placebo alongside insulin.

The pill - a novel liver-selective

glucokinase activator known as TTP399

- was associated with a placebosubtracted HbA1c reduction

of 0.32% at

12 weeks when compared with placebo.

"This may be the first adjunctive

therapy that can help people improve their

glycaemic control without increasing the

risk for hypoglycaemia," Carmen Valcarce,

Chief Scientific Officer of vTv Therapeutics,

said. "Fear of hypoglycaemia is what

keeps people from achieving their target

goals. That is the major take-home

message."

Research for adjunctive, oral

pharmacotherapies to treat type 1

diabetes has been limited by problems

in mangaging lows (hypoglycaemia)

and highs (in extreme cases, diabetic

ketoacidosis, or DKA).

TTP399 selectively activates

glucokinase, a key regulator of glucose

metabolism, in the liver. This activation

has been shown to increase glucose

utilisation, which in turn, lowers blood

glucose. Researchers said the drug

was well tolerated, with no DKA in

either treatment group and no severe

hypoglycaemia in the treated group and

one incident in the placebo group.

The findings from the phase 2

Simplici-T1 trial were presented at the

virtual European Association for the

Study of Diabetes (EASD) conference in

September.

www.vtvtherapeutics.com

Hotsteppers Awen-Haf and Llion Harding above and below.

Index

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