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6

NEWS

Research a 'step change'

Psoriasis link to T1

Children and adolescents with Type 1 diabetes had a higher

prevalence of psoriasis than children without the condition,

according to an Italian study. The letter to the editor, published

in the Journal of the European Academy of Dermatology and

Venereology, explains the study from 2017 to 2018 investigated

a link between psoriasis and Type 1 diabetes in children and

adolescents. Of the 166 patients enrolled in the study at the

Paediatric Diabetes Centre of Padua University, 8% were

affected by psoriasis, a prevalence four times higher than the

general Italian paediatric population. Study limitations include

a small cohort and no age- and BMI-matched control group.

Psoriasis diagnoses coincided with, or were after, Type

1 diagnoses, "suggesting a potential role of hyperglycaemia

in the onset of psoriasis in predisposed patients," said

the investigators. They suggest Th17 cells, which are

hypothesised to play roles in the pathogenesis of Type 1

diabetes and psoriasis, as a possible connection between the

two conditions.

Underlying T1 cause

Shares of Precigen have increased after the

company's Phase 1b/2a study of its AG019

ActoBiotics, designed to address the underlying

cause of Type 1 diabetes. The treatment was

studied in Phase 1b as a monotherapy for adults

aged 18-42 and adolescents aged 12-17. In

Phase 2a, it was used as a combination therapy

with teplizumab.

Pieter Rottiers, chief executive of Precigen's

ActoBio division, said in a statement that, "We are

encouraged by the Phase 1b/2a primary analysis

results and the implications for the potential of

AG019 as an easy-to-take oral monotherapy or

combination therapy with teplizumab, and that the

results "suggest the ability of AG019 to modulate

a patient's immune system in a precise, antigenspecific

manner to address the underlying cause of

Type 1 diabetes."

Researchers at Staffordshire

University have developed a low-cost

method to help prevent foot ulcers in

people with diabetes.

Millions of people with the

condition are at risk of developing

foot ulcers, which can often lead

to amputations and other health

complications. The scientists from

the Centre for Biomechanics and

Rehabilitation Technologies (CRBT)

have developed a new method to

reliably detect this risk without the

need for complex electronic inshoe sensors.

Dr Panagiotis Chatzistergos,

Associate Professor in Orthopaedic

Biomechanics, explains, "Routine

overloading of the sole of the foot

during daily activities can trigger

the onset of foot ulcers, so being

able to identify which areas in the

sole of the foot are most affected is

extremely important."

A common method involves

assessing plantar pressure to

prescribe special footwear or insoles,

however, many clinicians cannot use

this due to cost and difficulty to use.

Dr Chatzistergos and colleagues have

developed a novel concept to address

this problem, using 3D-printed,

tuneable structures that will help

clinicians better understand the

cause of ulcer development and

improve patient outcomes.

Patients would be required

to wear the sensor-insoles in

their everyday footwear for a

representative period, for example,

a day or a week, before returning

them for analysis. During the study of

the sensor-insole, plantar areas that

were routinely subjected to higher

pressures should be identifiable

against those where pressure was

below that threshold.

The concepts behind the work,

published in Royal Society Open

Science, have been fully developed at

Staffordshire University.

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