The Accelerator Hypothesis, Professor Terry Wilkin, the ADAPT trial, cure for Type 1 diabetes

LIVINGLIVING

The autoimmune diabetes Accelerator Prevention Trial (adAPT) is a new clinical

trial to find out whether an inexpensive drug can prevent Type 1 diabetes in

children at risk. It is now looking for participants, first in Scotland, and then in

the rest of the UK.

adAPT is a family study. The researchers are looking for siblings and offspring

aged between 5 and 16 years of people (their brothers, sisters or a parent) who

themselves developed T1D before the age of 25.

The trial will test whether Metformin, which is known to protect the insulin

cells from stress, can avoid the immune response that goes on to destroy them.

adAPT is sponsored by the University of Exeter, generously funded by JDRF

(Juvenile Diabetes Research Foundation) and conducted in the UK by TCTU

(Tayside Clinical Trials Unit).

www.adaptdiabetes.org

Preventing type 1 diabetes in children

Will you join us?

children do not yet have a disease, the

duration is long, and the discipline to take

the medication hard."

Statistical argument

The prevalence of Type 1 diabetes in the

childhood population is around 0.5%.

It is about 20-fold higher (10%) among

the siblings and offspring of people who

themselves developed Type 1 diabetes

before they were 25 years old, a risk

inflation related to the genes they share.

The risk in siblings and offspring is almost

nil in the absence of antibodies, slightly

increased (though not significantly so

after just five years) in those with a single

antibody, but 40% over the next five years

in those who have two or more antibodies.

So, if there are 100 children in the

trial on treatment (Metformin) and 100

children taking the placebo, the risk is

that 40 of those on the placebo will be

diagnosed with diabetes after five years.

The aim of the trial is to establish whether

a statistically smaller number develops

Type 1 diabetes who are on treatment

and, if so, to try and demonstrate why.

Summarising Wilkin says, "The aim

is to prevent more damage to beta cells.

Sadly, it is not likely to be a cure for

existing Type 1 diabetes, but it could be

a fundamental step along the road to its

prevention in the future."

It's a fascinating proposition, upturning

commonly held ideas about the pathology

of our disease. But if correct, it will help

prevent more diagnosis in the future. Any

progress is good progess.

If you think you might qualify to be

a participant, or know anyone else

lwho might, please contact the trial

(click on the advert below to be

taken to their website).

www.adaptdiabetes.org

TAKE PART!

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