Page 0016

KIT

I

n our mission to help people

with Type 1 diabetes lead

better, safer, healthier lives until

we ultimately find the cure,

JDRF funds research into the

development of new treatments for Type

1 diabetes.

As part of its hypoglycaemia

prevention efforts in 2006, JDRF

began funding early 'artificial pancreas'

research. Exactly one decade later, the

first generation artificial pancreas - also

knowns as a 'hybrid closed-loop system'

- became available in the US. This is the

Medtronic MiniMed 670G, the world's first

self-adjusting insulin pump system which

automates and personalises the delivery

of background (basal) insulin 24-hours a

day, and is due for commercial release in

the UK in 2019.

With these systems, blood glucose

levels are tracked through a continuous

glucose monitor (CGM). A computer

algorithm then takes the live data from

the CGM and works out whether glucose

levels are too high, too low, or just right,

and then tells an insulin pump what is

needed to keep glucose levels on track.

This means someone with Type 1

diabetes still has to work out how much

bolus insulin they need as a result of

what they eat. For that to no longer be

the case, the gap between the process

of eating and administering the required

CLOSED LOOP

EXPLAINED

An update on the closed-loop insulin delivery system being

funded by JDRF to treat Type 1 diabetes. By Rebecca Leitch,

who works at JDRF UK.

insulin needs to be fully closed, which

is when the right amount of insulin is

automatically provided at the right time -

including mealtimes.

Making progress

Professor Hovorka of the University of

Cambridge is developing a closed-loop

artificial pancreas with research funded by

JDRF and the National Institute for Health

Research (NIHR) at the NIHR Cambridge

Biomedical Research Centre.

His closed-loop artificial pancreas

will be an open protocol system (open

APS), so that any insulin pump, CGM

and algorithm can communicate with it,

regardless of the manufacturer. It is now

going through advanced human trials

after being found to be better at helping

people with Type 1 diabetes manage their

blood glucose levels by keeping them in

range 65% of time, compared with 54%

of the time without the technology.

However, this system still requires

rapid-acting insulin doses at meal

times. At the moment, the manmade

insulins available are not quick enough

to counteract the increase in glucose

in the blood after eating carbohydrate.

New insulins are therefore needed,

which is why JDRF has partnered with

Cambridge-based pharmaceutical

company, Arecor who began developing

a new, rapid-acting, ultra-concentrated

insulin in 2018.

But while progress on this is just

around the corner, JDRF continues to

have its eye on the ultimate treatment for

Type 1 diabetes - the cure - which we

know will be a reality one day.

www.jdrf.org.uk

"At the moment, the manmade insulins

available are not quick enough to

counteract the increase in glucose in

the blood after eating carbohydrate.

New insulins are therefore needed.

Index

  1. Desang diabetes magazine diabetes information
  2. Abbott Freestyle Libre, Flash Glucose Monitoring, blood testing without lancets
  3. Desang diabetes magazine diabetes information, Sue Marshall
  4. Desang diabetes magazine diabetes news
  5. Desang diabetes kitbags, free online diabetes magazine, diabetic kit
  6. Now Patient repeat prescription delivery service
  7. Now Patient repeat prescription delivery service
  8. Desang diabetes magazine diabetes news, Diabetes UK
  9. Now Patient repeat prescription delivery service
  10. Desang diabetes magazine diabetes news, Diabetes UK
  11. JDRF Type 1 tea party, raise awareness Type 1 diabetes
  12. Desang diabetes magazine diabetes diet
  13. Page 0013
  14. Roche Diabetes Care UK
  15. Dexcom CGM, continuous glucose monitoring
  16. Page 0016
  17. Input diabetes, help to get diabetes technology, access to diabetes technology
  18. Sleeping and diabetes, sleep and diabetes, diabetes and sleep
  19. Sleeping and diabetes, sleep and diabetes, diabetes and sleep
  20. Sleeping and diabetes, sleep and diabetes, diabetes and sleep
  21. Ascensia Contour Next One Diabetes blood test meters
  22. Sleeping and diabetes, sleep and diabetes, diabetes and sleep
  23. Ypsomed MyLife Diabetes care blood glucose monitoring systems
  24. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  25. Desang Diabetes Magazine, free diabetes magazine, living with diabetes
  26. Matthew Anson, blood testing, HbA1c, CGM and Time In Range
  27. Dexcom CGM, continuous glucose monitoring
  28. Page 0028
  29. Matthew Anson, blood testing, HbA1c, CGM and Time In Range
  30. Omnipod Insulet insulin pump with insulin pods, podders
  31. Omnipod Insulet insulin pump with insulin pods, podders
  32. Omnipod Insulet insulin pump with insulin pods, podders
  33. Omnipod Insulet insulin pump with insulin pods, podders
  34. Making Carbs Count, carb counting for diabetes
  35. Desang Diabetes Magazine, Making Carbs Count, carbohydrate counting for diabetes
  36. Accu-Chek Insight insulin pump
  37. Accu-Chek Insight insulin pump
  38. Desang Diabetes Magazine, free diabetes magazine, living with diabetes

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