Desang diabetes magazine diabetes news


continued over

JDRF-funded researchers have found

therapeutic potential of MANF protein to

reduce beta cell stress in Type 1 diabetes.

In the healthy pancreas of someone

without Type 1 diabetes, the hormone

insulin (essential for turning food into

energy) is produced, stored, and released

in a normal 'factory-like' process within

pancreatic beta cells in response to

glucose in the diet.

Early in the development of Type 1

diabetes excessive or pathologic stress


in beta cells compromises their ability to

properly secrete insulin. This triggers a

cascade of events ultimately contributing

to the beta cell death.

Over the past several years, JDRFfunded researchers

have found evidence

that beta cell stress may play a role in the

onset of T1D and are exploring ways to

prevent this occurring. This could protect

beta cell health and maintain normal beta

cell function.


Akers Biosciences, Inc., a leading

designer and manufacturer of rapid

diagnostic screening and testing products

has been granted a patent covering

Akers' Breath Ketone detection device.

The Breath Ketone detection device is

based upon Akers' proprietary MPC

Biosensor Technology which permits the

rapid identification of medical conditions

through biomarkers in exhaled breath.

The primary product being developed by

Akers using the Breath Ketone detection

device is the BreathKetone "Check",

which provides real-time diagnostic

information that allows diabetics and/

or their caregivers/healthcare providers

to determine if they have a severe level

of ketone (acid) build up in their body.

Ketone build up can cause ketoacidosis

which can require hospitalization if

untreated. The device has further

applications in the medical and nonmedical weight management areas


the measurement of ketone production is

used to monitor the burning of body fat.

As reported by Brenda Neugent in

Diabetes Health, two groups are

proposing a new definition of obesity that

considers factors beyond body mass


The American Association of Clinical

Endocrinologists (AACE) and the

American College of Endocrinology (ACE)

are calling for obesity to be defined by

obesity-related complications along with

body mass index.

The new definition, which includes five

different categories, will allow physicians

to better target treatments based on

individual needs, experts have said.

The five new proposed categories include:

1. Normal weight (BMI of less than 25).

2. Overweight (BMI of 25 to 29.9, no

obesity-related complications)

3. Obesity stage 0 (BMI of 30 or greater

and no obesity-related complications)

4. Obesity stage 1 (BMI of 25 or greater

with the presence of one or more mild to

moderate obesity-related complications).

5. Obesity stage 2 (BMI of 25 or greater

and the presence of one or more severe

obesity-related complications).

Obesity-related complications include

the following: metabolic syndrome, Type

2 diabetes, dyslipidemia, hypertension,

nonalcoholic fatty liver disease,

polycystic ovary syndrome, sleep apnea,

osteoarthritis, gastroesophageal reflux

disease and disability/immobility.





The Paediatric Diabetes Network (part of

Addenbrooke's Hospital) will be holding

the East of England games on 6 August

this year at Bedford Athletics Ground.

More than 15 teams of 30 children,

representing Type 1 clinics across the

region, will have the chance to take part

in a range of events showcasing their

sporting talents - from running the 100m

to welly-wanging!

You don't need to be a world-class

athlete to join in as long as you are

energetic and keen to meet other young

people with Type 1. The event is aimed

primarily at children with Type 1 diabetes.

For more information, if you live in the East

of England contact your local Diabetes

Specialist Nurse for more details about

how you can get involved. You need to be

under 16 to take part.

There is also a JDRF, for which you can sign

up here, or email Hannah Roberts at


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