Dr Philip Toleikis, Sernova, Cell Pouch technology, islet cell transplants, glucose responsive techn

KITLIVING

as in previous transplant trials. In a small

human study, the device has been proven

safe, and the cells are able to survive,

produce insulin, and link up naturally to the

blood system - a very important first step."

JDRF is helping to fund the next human

clinical trial about to be undertaken in the

US. Previous research has been done

in Canada. How permanent the implant

works will depend on how long the cells

last. Says Toleikis, "We are still learning

about that. The device is implanted,

then there is a wait for a period of twoto-four weeks while it starts to develop

the tissue-lined chambers with the blood

supply. Then the cells are transplanted.

They will start release releasing insulin

into the bloodstream. Cell Pouch islets

are glucose responsive, meaning that

the cells that produce insulin have a

mechanism inside that reads glucose

levels and they will then release insulin

into the blood system if glucose is high.

They turn on or off according to glucose

levels and are much more accurate than

any CGM-and-insulin pump combination.

We are aiming for patients to be making

their own insulin again and for no insulin

injections or infusion pumps or CGM to

be necessary."

While human donor islets are great,

there is a need for an unlimited supply of

cells. There are two types of stem cells.

First are progenitor cells, which develop

in the body over time. Then there are fully

differentiated cells. These can function

straightaway. Sernova is assessing the

best technologies for the Cell Pouch.

These cells can provide an unlimited

supply to treat millions of people.

"If our technologies prove successful,"

says Toleikis, "There should be fewer

doctor visits, far fewer side-effects thereby

reducing the real cost of diabetes in both

human and financial terms."

www.sernova.com

*Although this is well documented, this specific

information was taken from a page on the website

of www.diabetes.org.uk

The Edmonton Protocol: Researchers

at the University of Alberta in Edmonton,

Canada. These scientists have used a

procedure called the Edmonton Protocol

to treat patients with Type 1 diabetes who

have severe hypoglycaemia unawareness.

In this procedure, researchers use

specialized enzymes to remove islets

from the pancreas of a deceased donor.

For an average-size person (70 kg),

a typical transplant requires about 1

million islets, equal to two donor organs.

Because the islets are extremely fragile,

transplantation occurs immediately after

they are removed. The surgeon uses

ultrasound to guide placement of a small

plastic tube (catheter) through the upper

abdomen and into the liver. The islets are

then injected through the catheter into

the liver. It takes some time for the cells

to attach to new blood vessels and begin

releasing insulin. Immunosuppressive

(anti-rejection) drugs are needed to

keep the transplanted islets functioning.

Researchers do not fully know what longterm effects

these drugs may have. More

research is needed to answer questions

about how long the islets will survive and

how often the transplantation procedure

will be successful. (American Diabetes

Association).

Glucose responsive technology:

The cells that produce insulin have a

mechanism inside that reads glucose

levels and they will then release insulin into

the blood system if glucose is high. They

are glucose responsive as they turn on or

off according to glucose levels.

Islet cells: The pancreatic islets, or

islets of Langerhans, are the regions of

the pancreas that contain its hormoneproducing

cells, discovered in 1869 by

pathological anatomist Paul Langerhans.

Microencapsulation: A microcapsule is

a small sphere with a uniform wall around

it. The material inside the microcapsule is

referred to as the core, internal phase, or

fill, whereas the wall is sometimes called

a shell, coating, or membrane. It is mainly

used to increase the stability and life of the

product being encapsulated.

Regenerative medicine: a branch of

translational research in tissue engineering

and molecular biology which deals with

the "process of replacing, engineering

or regenerating human cells, tissues or

organs to restore or establish normal

function". (Wikipedia). This branch of

medicine includes stem cell research.

GLOSSARY

Index

  1. Desang diabetes magazine diabetes information
  2. Abbott Freestyle Libre, Flash Glucose Monitoring, blood testing without lancets
  3. Desang diabetes magazine diabetes information, Sue Marshall
  4. diabetes news, novo nordisk insulin fiasp
  5. diabetes news, Medtronic, Medtronic Guardian Connect, BiAP
  6. diabetes news, Dr John Fossey, glucose
  7. Novo Nordisk diabetes mealtime management
  8. diabetes care, pocket medic, Kimberley Littlemore, Type 2 diabetes
  9. diabetes care, pocket medic, Kimberley Littlemore, Type 2 diabetes
  10. Ten Acre crisps, Jacob's Crackers
  11. A1C self check, HbA1c, Sweet Freedom
  12. Jean Cazels photography, British sandwiches, Heinz Seriously good mayo
  13. Ascensia Contour Diabetes blood test meters
  14. Accu-Chek Mobile blood glucose system
  15. Accu-Chek Mobile blood glucose system
  16. Redring tea survey, The Tea Terrace,
  17. Ecoffee, Costa Coffee
  18. Sue Marshall diabetes Professor Nick Oliver Imperial College London
  19. Professor Nick Oliver Imperial College London, BiAP, bio-inspired artificial pancreas, ABC4D, Chris
  20. Dr Philip Toleikis, Sernova, Cell Pouch technology, islet cell transplants, glucose responsive techn
  21. Dr Philip Toleikis, Sernova, Cell Pouch technology, islet cell transplants, glucose responsive techn
  22. Making Carbs Count, greek yoghurt
  23. Making Carbs Count, greek yoghurt
  24. Accu-Chek Insight insulin pump, making carbs count
  25. Accu-Chek Insight insulin pump
  26. Free diabetes magazine, Desang diabetes magazine,

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